ANTI-BIOFILM DENTAL MATERIALS

The oral cavity is a harsh environment for restored tooth structure. Secondary caries is a common cause of teeth/restoration failure due to acids produced by biofilm, microleakage and cyclic stresses from mastication. 

We fabricated a novel resin-based dental material with anti-caries agents (nanoparticles of silver, antibacterial macromolecules and amorphous calcium phosphate). These type of materials are used to fill restorations.

Novel agents embedded in the resin, prevented biofilm adhesion and neutralized acids produced by bacteria. Our results showed a significant improvement of the bonding durability and strength, extending restorations life.

We designed an in-vitro study to expose dentin-restoration complex to biofilm/acidic environment during cyclic loading representing mastication (see left Figure below). 

Dentin

Failure

Our experimental results revealed the new multi-agent dental composite reduced the acidic impact of the oral biofilm at the bonding interface, by improving the resistance to fatigue failure. 

 

In summary, this study shows that dental restorative materials containing multiple therapeutic agents of different chemical characteristics can be beneficial toward improving resistance to mechanical and acidic challenges in oral environments.

We also revealed the mechanisms responsible for the improvement of the properties (see SEM image above).

For details please refer to the published article on APS Applied Materials & Interfaces. Results from this multi-disciplinary work were obtained with collaborative efforts between groups with expertise in fracture mechanics of biomaterials and microbiology and dental caries.

Collaborators:

 

Future Reading:

1.Melo, Mary Anne, Orrego, Santiago, et al. "Designing Multiagent Dental Materials for Enhanced Resistance to Biofilm Damage at the Bonded Interface." ACS applied materials & interfaces 8.18 (2016): 11779-11787.

 

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